Year 2015 / Volume 107 / Number 12
Original
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients

740-744

DOI: 10.17235/reed.2015.3851/2015

Banu Demet Coskun, Engin Altinkaya, Eylem Sevinc, Mustafa Ozen, Hatice Karaman, Ahmet Karaman, Orhan Poyrazoglu,

Abstract
Background: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it with other noninvasive tests for predicting significant fibrosis. This study was the second to evaluate the globulin/platelet model in HBV patients. Methods: We retrospectively investigated 228 patients with chronic hepatitis B who performed liver biopsy from 2013 to 2014. The globulin/platelet model, APGA [AST/Platelet/Gamma-glutamyl transpeptidase/Alfa-fetoprotein], FIB4, fibrosis index, cirrhosis discriminate score, and Fibro-quotient were calculated, and the diagnostic accuracies of all of the fibrosis indices were compared between the F0-2 (no-mild fibrosis) and F3-6 (significant fibrosis) groups. Results: All of the noninvasive markers were significantly correlated with the stage of liver fibrosis (p < 0,001). To predict significant fibrosis (F ≥ 3), the area under the curve (95% CI) was found to be greatest for APGA (0.83 [0.74-0.86]), followed by FIB-4 (0.75[0.69-0.80]), the globulin/platelet model (0.74 [0.68-0.79]), fibrosis index (0.72 [0.6-0.78], cirrhosis discriminate score (0.71 [0.64-0.76]) and Fibro-quotient (0.62 [0.55-0.7]). The area under the receiver operating characteristic curves of APGA was significantly higher than that of the other noninvasive fibrosis markers (p < 0.05). Conclusions: While the APGA index was found to be the most valuable test for the prediction significant fibrosis in patients with chronic hepatitis B, GP model was the thirth valuable test. Therefore, we recommended that APGA could be used instead of the GP model for prediction liver fibrosis.
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Coskun B, Altinkaya E, Sevinc E, Ozen M, Karaman H, Karaman A, et all. The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients. 3851/2015


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Publication history

Received: 16/05/2015

Accepted: 08/08/2015

Online First: 22/10/2015

Published: 03/12/2015

Article revision time: 53 days

Article Online First time: 159 days

Article editing time: 201 days


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